Adjuvant high-dose interferon for cutaneous melanoma is most beneficial for patients with early stage III disease
نویسندگان
چکیده
منابع مشابه
Adjuvant therapy for resected stage III melanoma patients: high-dose interferon-alpha versus ipilimumab combined with kinases inhibitors.
High-dose interferon-alpha remains the first-line treatment in the adjuvant therapy of metastatic melanoma. More recently, high-dose pegylated interferon-alpha-2b has been approved by the US Food and Drug Administration. Actually, an adjuvant therapy alternative to high-dose interferon-alpha is represented by ipilimumab. Moreover, combination therapy of IFN-alpha or ipilimumab with tyrosine kin...
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In their recent review, Punt and Eggermont [1] state that “combined data from low-dose IFN-α [interferon-α] trials does not suggest a benefit in ... DFS [disease-free survival]”. This conclusion is inconsistent with the results of a metaanalysis of these trials [2]. It is surprising that Punt and Eggermont [1] do not mention this study, especially as the latter was an author on the meta-analysi...
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The author poses the question “Why did these study results not lead to a global consensus about interferon treatment as standard of care?” The answer is quite simple: The E1684 adjuvant high-dose interferon (hdifn) trial, while initially positive, was later shown to be negative. Remarkably, in spite of a p value of 0.09, the principal investigator still interpreted the trial as positive 1. Canc...
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KG The first step is to determine the risk of relapse and death for individual patients. Presently, the factors that guide our risk prediction are the presence or absence of a positive sentinel lymph node, the thickness of the tumor, the mitotic rate, and the presence or absence of ulceration. The current American Joint Committee on Cancer (AJCC) melanoma staging manual, published in 2009 by Ba...
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ژورنال
عنوان ژورنال: Cancer
سال: 2008
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.23399